|
KMID : 1132720100080010034
|
|
Genomics & Informatics
2010 Volume.8 No. 1 p.34 ~ p.40
|
|
|
Classification of Biological Effect of 1,763 MHz Radiofrequency Radiation Based on Gene Expression Profiles
|
|
Im Chang-Nim
Kim Eun-Hye
Park Ae-Kyung
Park Woong-Yang
|
|
|
Abstract
|
|
|
|
Radiofrequency (RF) radiation might induce the transcription of a certain set of genes as other physical stresses like ionizing radiation and UV. To observe transcriptional changes upon RF radiation, we exposed WI-38, human lung fibroblast cell to 1763 MHz of mobile phone RF radiation at 60 W/kg of specific absorption rate (SAR) for 24h with or without heat control. There were no significant changes in cell numbers and morphology after exposure to RF radiation. Using quantitative RT-PCR, we checked the expression of three heat shock protein (HSP) (HSPA1A, HSPA6 and HSP105) and seven stress-related genes (TNFRSF11B, FGF2, TGFB2, ITGA2, BRIP1, EXO1, and MCM10) in RF only and RF/HS groups of RF-exposed cells. The expressions of three heat shock proteins and seven stress-related genes were selectively changed only in RF/HS groups. Based on the expression of ten genes, we could classify thermal and non-thermal effect of RF-exposure, which genes can be used as biomarkers for RF radiation exposure.
|
|
|
KEYWORD
|
|
|
biomarker, heat shock, quantitative RT-PCR, radiofrequency radiation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|